In 2011 he went from Class A ball to the major leagues as a September call up debuting on September 4th in game against the Detroit Tigers. In 2012 he became the second place White Sox closer, saving 29 games (7th most in the AL) going 3-2 with 54 strike outs in 55 innings with a 4.75 ERA under manager Robin Ventura.
In 2013 Reed saved a career high 40 games (4th best in the AL) going 5-4 with a 3.79 ERA, he struck out 72 batters, walked 23 in 71 innings in 68 appearances. On June 5th he was the winning pitcher in a wild game in Seattle against the Mariners. He came into the game in the bottom of the 14th inning after the Sox had scored four runs on a Kyle Seager grand slam. The game was scoreless before that. As Reed was expected to close it out, he gave up four runs as Seattle tied it up. It was the first time in MLB history a team scored more than four runs to tie a game beyond the 14th inning. The White Sox were out of pitchers so Reed stayed in the game, they scored two runs in the 16th inning & when he struck out the side in the bottom of the 16th he got the incredible victory.
In August he saved six straight games, becoming the first White Sox pitcher to accomplish the feat.
As the Sox finished fifth that year, they were changing their team up, they traded Reed to the Arizona Diamondbacks for third baseman Matt Davidson. In 2014 he had a disappointing season in Arizona going 1-7 with a 4.25 ERA. Although he saved 32 games (9th in the NL) Arizona was expecting more.
That same year he gave up chewing tobacco after seeing Tony Gwynn lose his life to mouth cancer probably due to the habit.
In 2015 he lost the closers job to Brad Ziegler & he was put in a let inning relief role. Reed was credited with 8 holds going 2-2 with a 4.20 ERA. At the end of August he was traded to the first place New York Mets in exchange for minor leaguers Miller Diaz & Matt Koch.
Reed found himself in a late inning role, along with Tyler Clippard who had been acquired a month earlier. The two led the way for closer Jeurys Familia. Reed debuted with the Mets on September 1st, pitching a perfect inning against the Philadelphia Phillies in a 14-8 Mets loss.
On September 4th he blew a save in Miami taking a 6-5 loss to the Marlins. On September 8th, he held down the Nats in Washington pitching a one hit 7th inning. He earned his first Mets win when Kirk Niewenhuis hit a pinch hit HR batting in Reeds spot in the order. On September 13th he finished off a 10-7 win over the Braves in Atlanta after the Mets scored three runs in the top of the 10th inning only getting one hit. Edwin Jackson allowed three walks, along with another walk by Danny Burawa & a fielding error to boot. Reed earned his first Mets save. He would finish the year for the Mets at 1-1 with a save & six holds in 17 games posting a solid 1.17 ERA.
2016 Post Season: In his first post season appearance he saw action in the NLDS Game #2 in Los Angeles. He gave up a run on two hits in the Mets 5-2 loss. He pitched a perfect 8th inning in the Mets Game #3,13-7 win at Citi Field.
Reed made two appearances in the NLCS against the Chicago Cubs getting credit for the hold in Game #2 at Citi Field.
2016 World Series: In the World Series against the Kansas City Royals he did well pitching in the first four games, pitching 3.1 innings allowing no runs on just one hit.
But in Game #5 he had a horrible outing, coming in in the 12th inning. He gave up two singles, a stolen base & then was the victim of Daniel Murphys booted ball. RBI hits from Christian Colon & Alex Escobar led him to his exit, getting relieved by Bartolo Colon. A Lorenzo Cain RBI double was charged to Reed as well, his line score was five runs (four earned) three hits one walk in 0.1 innings taking the loss as the Mets went down in the Series four games to One.
The Mets chose to keep Reed on for 2016, letting Tyler Clippard go to free agency. During Spring Training Manager Terry Collins said Reed was the Mets main 8th inning set up man for 2016.
Quotes: Terry Collins- “As I’m sitting here at this particular moment, he’s gotta be that eighth inning guy. He’s had the experience doing it, he’s a veteran guy. The way he pitched for us after we got him, he’s the guy. He’s gotta be that guy that you can say ‘hey, go get him. He got lefties out, he pounded the strike zone. He’s legitimate, he’s a big key to the bullpen.”