By 2006 he was on the Angels roster as their main catcher over Jose Molina. Napoli entered the major leagues with a HR in his first career at bat, coming against the Detroit Tigers. Overall in his rookie year he hit 16 HRs with 13 doubles in 94 games, although he only batted .228. By 2008 he brought his average up to .273 and would hit over 20 HRs in each of the next three seasons.
In 2010 he had his best Angels season playing in 140 games, with 108 hits, 26 HRs, 68 RBIs, 24 doubles & 60 runs scored. His batting average did fall to .238 & he struck out 137 times (7th in the league). In Anaheim he played in three post seasons, hitting a pair of HRs with four RBIs in the 2007 ALCS against the Boston Red Sox.
In January 2011 he was traded to the Toronto Blue Jays along with Juan Rivera for Vernon Wells. Four days later he was sent to the Texas Rangers for Frank Francisco. Napoli would share time during the regular season behind the plate (61 games) with veteran Yorvit Torrealba (98 games).
Napoli would play at first base as well as designated hitter and have an incredible year at the plate. He hit .320 although his 369 at bats did not qualify him in the batting leaders, hit 30 HRs (10th in the league) with 25 doubles & 75 RBIs playing in 116 games over all. He saw more playing time behind the plate in September & by the post season he was the Rangers main backstop.
Post Season: In the 7th inning of Game #3 of the 2011 ALDS he hit a two run HR off Tampa’s Dave Price putting the Rangers ahead 2-1, in a game they would win 4-3. In the Series he batted .357 (4-15). He had a good ALCS against the Detroit Tigers as well, batting .292 with an RBI & six runs scored.
In the World Series he became a household name & a Texas baseball legend as the fans in the Dallas / Fort Worth metroplex chanted Napoli -Napoli!! In Game #1 he hit a two run HR off Chris Carpenter to tie the game at two, although Texas went onto lose 3-2.
In Game #4 he greeted new pitched Mitchell Boggs with a tremendous three run HR in the 6th inning sealing the Rangers 4-0 win, tying the series at two games each. In Game #5 he came to the plate in the bottom of the 8th inning with the bases loaded & the score tied 2-2. Napoli lined a double to centerfield scoring two runs, leading the Rangers to a three games to two series lead.
In the classic Game #6 he broke a 4th inning 2-2 tie with an RBI single, overall in the series he lead all teams with 10 RBIs. He batted .350 (second for Texas behind Ian Kinsler) with seven hits & two HRs.
In 2012 Napoli returned with a one year deal to avoid arbitration. He played in 108 games, slugging 24 HRs but his average fell to .227 with 56 RBIs. Texas lost their hold on first place in the final days of the season & lost the first round of the new one game Wild Card Playoff.
For 2013 he signed on with a one year deal for the Boston Red Sox, as the teams primary first baseman. Napoli was second to slugger David Ortiz on the club in HRs (23) & RBIs (92). His 38 doubles were tied with Ortiz for best on the Sox team. Napoli also went down swinging 187 times.
Post season: In the ALDS against the Tampa Rays he went just 2-12. In the ALCS he was the hero of Game #3 at Detroit, hitting a HR off the Tigers' Justin Verlander, while scoring the only run of the game in John lackey's 1-0 victory. In Game #5 he hit a HR off Anibal Sanchez in the Red Sox three run 2nd inning.
In the Red Sox World Series win over the St. Louis Cardinals, Napoli drove in three runs with a double in the Game #1 Red Sox 8-1 victory. He would get just one more hit in the five game series, an RBI single in the clincher game five.
That December he signed another deal with Boston for 2014. In 2014 as the Red Sox fell to fifth place, Napoli hit .248 with 17 HRs 20 doubles & 55 RBIs. In his nine year career, Napoli is hitting .257 with 819 hits 186 HRs 171 doubles 527 RBIs while striking out 993 times in 313 at bats in 985 games.
Napoli suffers from sleep apnea & will undergo facial reconstructive surgery to hopefully cure the issue up. "I've been dealing with sleep apnea for a long time, my whole career. I've tried numerous things and none of them worked. Dental mouth piece, CPAP machine, medicines ... It's just gotten to the point where I have to get this done."
Trivia: Napoli has been linked to a realation ship with model Alison McDaniel.